Orly served in the IDF as a technology trainer and commander. She then relocated to Maastricht, the Netherlands as a mechanics and electronics engineer for Indigo, an Israeli startup in the printing industry that was later acquired by HP.  

She then studied at Maastricht University where she completed her Master's degree in International Business and Finance as well as an MBA, with her dissertation written for McKinsey & Co. on the topic of biotechnology startup valuation. Orly worked for McKinsey and Co. in Belgium, France, and Israel in the Fast Growth Tech division.

 Orly also lived for 10 years in California, USA where she worked for Merrill Lynch in asset management and private banking. During this time, she invested in and was the chairperson of technology startups as well as a lecturer at the UCI Merage Foundation Innovation Leadership Program. Orly is a guest speaker at Tel Aviv University.